Structure of PDB 3ihz Chain A

Receptor sequence
>3ihzA (length=123) Species: 5855 (Plasmodium vivax) [Search protein sequence]
ETLEQVHLTEDGGVVKTILRKGEGGEENAPKKGNEVTVHYVGKLESSGKV
FDSSRERNVPFKFHLGQGEVIKGWDICVASMTKNEKCSVRLDSKYGYGEE
GCGESIPGNSVLIFEIELISFRE
3D structure
PDB3ihz NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35
ChainA
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y43 F54 D55 I74 Y100 F117
Catalytic site (residue number reindexed from 1) Y40 F51 D52 I71 Y97 F114
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FK5 A Y43 D55 F64 V73 I74 W77 Y100 F117 Y40 D52 F61 V70 I71 W74 Y97 F114 MOAD: ic50=160nM
PDBbind-CN: -logKd/Ki=6.80,IC50=160nM
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:3ihz, PDBe:3ihz, PDBj:3ihz
PDBsum3ihz
PubMed20572013
UniProtA5K8X6

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