Structure of PDB 3ihp Chain A

Receptor sequence
>3ihpA (length=673) Species: 9606 (Homo sapiens) [Search protein sequence]
MAELSEEALLSVLPTIRVPKAGDRVHKDECAFSFDTPESEGGLYICMNTF
LGFGKQYVERHFNKTGQRVYLHLRRTDEDVKIVILPDYLEIARDGLGGLP
DIVRDRVTSAVEALLSVRQVSKHAFSLKQLDNPARIPPCGWKCSKCDMRE
NLWLNLTDGSILCGRRYDGSGGNNHAVEHYRETGYPLAVKLGTITPDGAD
VYSYDEDDMVLDPSLAEHLSHFGIDMPLFGPGYTGIRNLGNSCYLNSVVQ
VLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEDGIA
PRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNCRSSENPNEVFRF
LVEEKIKCLATEKVKYTQRVDYIMQLPVPMDAALNKEELLEYEEKKRQAE
EEKMALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFA
SFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDISQLRGTGLQPGEEE
LPDIESVIIQLVEMGFPMDACRKAVYYTGNSGAEAAMNWVMSHMDDPDFA
NPLILPPPEDCVTTIVSMGFSRDQALKALRATNNSLERAVDWIFSHIDDL
DAEAAMDPKVRDGPGKYQLFAFISHMGTSTMCGHYVCHIKKEGRWVIYND
QKVCASEKPPKDLGYIYFYQRVA
3D structure
PDB3ihp Covalent Ubiquitin-Usp5 Complex
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C199 C219 H232 C143 C163 H175
BS02 NEH A N333 C335 Q433 N241 C243 Q320
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008270 zinc ion binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0101005 deubiquitinase activity
Biological Process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108 protein K48-linked deubiquitination
GO:0140251 regulation protein catabolic process at presynapse
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005829 cytosol
GO:0098793 presynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ihp, PDBe:3ihp, PDBj:3ihp
PDBsum3ihp
PubMed
UniProtP45974|UBP5_HUMAN Ubiquitin carboxyl-terminal hydrolase 5 (Gene Name=USP5)

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