Structure of PDB 3iex Chain A

Receptor sequence
>3iexA (length=276) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGGVKDKITIPYTKIPN
FPQTSSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKLLGVK
ILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAFGTRF
PALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAECTML
LNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKPNHEE
VLATGAQRAELMQSWFEKIIEKLPKD
3D structure
PDB3iex Structural basis for selective inhibition of purine nucleoside phosphorylase from Schistosoma mansoni: kinetic and structural studies
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S35 H88 Y90 E91 A118 M221 S222 N245 S247 H259
Catalytic site (residue number reindexed from 1) S32 H77 Y79 E80 A107 M210 S211 N234 S236 H248
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GMP A Y90 A118 A119 G120 Y202 E203 V219 G220 M221 N245 H259 V262 Y79 A107 A108 G109 Y191 E192 V208 G209 M210 N234 H248 V251
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047975 guanosine phosphorylase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3iex, PDBe:3iex, PDBj:3iex
PDBsum3iex
PubMed20129792
UniProtQ9BMI9

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