Structure of PDB 3ici Chain A

Receptor sequence
>3iciA (length=187) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLGSDEKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVAL
ATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFK
LKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVV
RKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
3D structure
PDB3ici Structural Basis of Cyclophilin B Binding by the Calnexin/Calreticulin P-domain.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R63 F68 Q71 N110 F121 L130 H134
Catalytic site (residue number reindexed from 1) R66 F71 Q74 N113 F124 L133 H137
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K4 K6 G7 P8 K9 K35 T36 K97 K183 K8 K9 G10 P11 K12 K38 T39 K100 K186
BS02 ZN A G-3 D2 G1 D6
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0016018 cyclosporin A binding
GO:0051082 unfolded protein binding
GO:0070063 RNA polymerase binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding
GO:0030593 neutrophil chemotaxis
GO:0040018 positive regulation of multicellular organism growth
GO:0044794 positive regulation by host of viral process
GO:0044829 positive regulation by host of viral genome replication
GO:0050821 protein stabilization
GO:0060348 bone development
GO:0061077 chaperone-mediated protein folding
GO:1901873 regulation of post-translational protein modification
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005790 smooth endoplasmic reticulum
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0034663 endoplasmic reticulum chaperone complex
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ici, PDBe:3ici, PDBj:3ici
PDBsum3ici
PubMed20801878
UniProtP23284|PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B (Gene Name=PPIB)

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