Structure of PDB 3ibj Chain A

Receptor sequence
>3ibjA (length=661) Species: 9606 (Homo sapiens) [Search protein sequence]
YTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNL
QLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSM
LGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHY
TSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEAR
NLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATT
GQILNIPDAYAHPLFSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPW
FSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVS
DDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNF
INNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELT
NYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMER
HHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFK
DLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYK
EFFSQGDLEKAEKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVA
SNREHWTKVSH
3D structure
PDB3ibj Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.
ChainA
Resolution3.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H660 H696 D697 D808 H432 H468 D469 D580
BS02 MG A D697 T768 D469 T540
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3ibj, PDBe:3ibj, PDBj:3ibj
PDBsum3ibj
PubMed19828435
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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