Structure of PDB 3i8v Chain A

Receptor sequence
>3i8vA (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
HMNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMI
FQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVL
LATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYND
ESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSK
HMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKP
LELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDY
IVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAI
3D structure
PDB3i8v Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H376 H412 D413 D530 H89 H125 D126 D243
BS02 0MO A M485 T545 I548 M549 F552 M569 Q581 F584 M198 T258 I261 M262 F265 M282 Q294 F297 BindingDB: IC50=4300nM,EC50=3300nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3i8v, PDBe:3i8v, PDBj:3i8v
PDBsum3i8v
PubMed
UniProtP27815|PDE4A_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4A (Gene Name=PDE4A)

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