Structure of PDB 3i3w Chain A

Receptor sequence

>3i3wA (length=441) Species: 119856 (Francisella tularensis subsp. tularensis)

KYFGTDGIRGEVANSTITVEFTQKLGNAVGSLINQKNYPKFVIVGQDTRS
SGGFLKFALVSGLNAAGIDVLDLGVVPTPVVAFMTVKHRAAAGFVITASH
NKFTDNGIKLFSSNGFKLDDALEEEVEDMIDGDFIYQPQFKFGSYKILAN
AIDEYIESIYSRFAKFVNYKGKVVVDCAHGAASHNFEALLDKFGINYVSI
ASNPDGLNINVGCGATCVSNIKKAVKEQKADLGISLDGDADRIIIVDENG
QEIDGDGILNILAQYSDICGGTNGIVGTQMTNMSYENHYRANKIPFIRSK
VGDRYVLEDLVKYGYKIGGESSGHVINLNFGTTGDGLFTAIQLLAIFSQA
DKPVSEFKLQGELMQQTLINVPLTKKVAREDLQKVASDVNDVEKRLGNRG
RVLLRPSGTEPVLRVMVEADDKSLATNEAEYLVEKVKQKLV

3D structure

• PDB: 3i3w Structure of a phosphoglucosamine mutase from Francisella tularensis
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R11 S101 H102 K111 D239 D241 D243 R244 H326
• Catalytic site (residue number reindexed from 1): R9 S99 H100 K109 D237 D239 D241 R242 H324
• Enzyme Commision number: 5.4.2.10: phosphoglucosamine mutase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	S101 D239 D241 D243	S99 D237 D239 D241

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004615 phosphomannomutase activity
• GO:0008966 phosphoglucosamine mutase activity
• GO:0016853 isomerase activity
• GO:0016868 intramolecular phosphotransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0006048 UDP-N-acetylglucosamine biosynthetic process
• GO:0009252 peptidoglycan biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:3i3w, PDBe:3i3w, PDBj:3i3w
• PDBsum: 3i3w
• UniProt: Q5NII8|GLMM_FRATT Phosphoglucosamine mutase (Gene Name=glmM)