Structure of PDB 3hzt Chain A

Receptor sequence
>3hztA (length=421) Species: 508771 (Toxoplasma gondii ME49) [Search protein sequence]
SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALL
DEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFS
EVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFG
LSAHFEVGTAYYIAPEVLRKKYDEKCDVWSCGVILYILLCGYPPFGGQTD
QEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNH
PWIVKFCSQVGKHALTGALGNMKKFQSSQKLAQAAMLFMGSKLTTLEETK
ELTQIFRQLDNNGDGQLDRKELIEGYRKLMQWSSQIEAEVDHILQSVDFR
NGYIEYSEFVTVCMDKQLLLSRERLLAAFQQFDSDGSGKITNEELGRLFG
VTEGEVDFEEFVEMMQKICDV
3D structure
PDB3hzt Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D199 K201 E203 N204 D220 T239
Catalytic site (residue number reindexed from 1) D127 K129 E131 N132 D148 T159
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D394 N396 D398 Q400 Y447 D310 N312 D314 Q316 Y353
BS02 J60 A L82 A103 M153 E154 V155 Y156 L206 D220 L10 A31 M81 E82 V83 Y84 L134 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3hzt, PDBe:3hzt, PDBj:3hzt
PDBsum3hzt
PubMed20436473
UniProtQ3HNM6

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