Structure of PDB 3hzi Chain A

Receptor sequence
>3hziA (length=423) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
PKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGN
ITSDAVFNFFDNLLPDSPIVRDRIVKRYHAKSRQPFDLLSEIGRDSVGAV
TLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREDFRISVAG
AQEKTALLRIGNDWCIPKGITPTTHIIKLPILSQSVDNEYYCLLLAKELG
LNVPDAEIIKAGNVRALAVERFDRRWNARRTVLLRLPQEDMCQTFGLPSS
VKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATQGHAKN
FSVFIQAGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKT
AIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSLPTDF
PENVVTAVESNVLRLHGRLSREY
3D structure
PDB3hzi Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
ChainA
Resolution2.98 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V98 A152 G153 A154 Q155 K157 I179 K181 F236 D237 Q252 H311 Y331 D332 V97 A149 G150 A151 Q152 K154 I176 K178 F222 D223 Q238 H297 Y317 D318
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0000976 transcription cis-regulatory region binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0043565 sequence-specific DNA binding
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0016310 phosphorylation
GO:0022611 dormancy process
GO:0040008 regulation of growth
GO:0044010 single-species biofilm formation
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol
GO:0032993 protein-DNA complex
GO:0110001 toxin-antitoxin complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3hzi, PDBe:3hzi, PDBj:3hzi
PDBsum3hzi
PubMed19150849
UniProtP23874|HIPA_ECOLI Serine/threonine-protein kinase toxin HipA (Gene Name=hipA)

[Back to BioLiP]