Structure of PDB 3hy7 Chain A

Receptor sequence
>3hy7A (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
SRARQVELLLVADASMARKYGRGLQHYLLTLASIANRLYSHASIENHIRL
AVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAI
LFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIG
HLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEF
LDDGHGNCLLDLPRKQI
3D structure
PDB3hy7 Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
ChainA
Resolution1.69 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 097 A D377 T378 L379 G380 H410 E411 H414 H420 S441 I442 L443 D114 T115 L116 G117 H147 E148 H151 H157 S178 I179 L180 MOAD: ic50=106nM
PDBbind-CN: -logKd/Ki=6.97,IC50=106nM
BindingDB: IC50=10000nM
BS02 ZN A H410 H414 H420 H147 H151 H157
BS03 CA A E270 D353 D360 C471 D474 E7 D90 D97 C208 D211
BS04 CA A E270 D353 D474 E7 D90 D211
BS05 CA A D369 L370 C376 T378 E398 D106 L107 C113 T115 E135
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3hy7, PDBe:3hy7, PDBj:3hy7
PDBsum3hy7
PubMed19586907
UniProtQ9UNA0|ATS5_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 5 (Gene Name=ADAMTS5)

[Back to BioLiP]