Structure of PDB 3hxx Chain A

Receptor sequence
>3hxxA (length=441) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SKSTAEIRQAFLDFFHSKGHQVVASSSLVPHNDPTLLFTNAGMNQFKDVF
LGLDKRNYSRATTSQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGD
YFKLDAILFAWLLLTSEKWFALPKERLWVTVYESDDEAYEIWEKEVGIPR
ERIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPPGSP
EEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERIAAVLQHV
NSNYDIDLFRTLIQAVAKVTGATDLSNKSLRVIADHIRSCAFLIADGVMP
SNENRGYVLRRIIRRAVRHGNMLGAKETFFYKLVGPLIDVMGSAGEDLKR
QQAQVEQVLKTEEEQFARTLERGLALLDEELAKLSGDTLDGETAFRLYDT
YGFPVDLTADVCRERNIKVDEAGFEAAMEEQRRRAREASGF
3D structure
PDB3hxx Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
ChainA
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.7: alanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A R69 D76 R85 H86 H87 F90 M92 W170 E209 I210 N212 G237 G239 R242 R69 D76 R85 H86 H87 F90 M92 W170 E209 I210 N212 G237 G239 R242
BS02 MG A E183 E209 E183 E209
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006419 alanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hxx, PDBe:3hxx, PDBj:3hxx
PDBsum3hxx
PubMed20010690
UniProtP00957|SYA_ECOLI Alanine--tRNA ligase (Gene Name=alaS)

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