Structure of PDB 3hxu Chain A

Receptor sequence
>3hxuA (length=441) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SKSTAEIRQAFLDFFHSKGHQVVASSSLVPHNDPTLLFTNAGMNQFKDVF
LGLDKRNYSRATTSQRCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGD
YFKLDAILFAWLLLTSEKWFALPKERLWVTVYESDDEAYEIWEKEVGIPR
ERIIRIGDNKGAPYASDNFWQMGDTGPCGPCTEIFYDHGDHIWGGPPGSP
EEDGDRYIEIWNIVFMQFNRQADGTMEPLPKPSVDTGMGLERIAAVLQHV
NSNYDIDLFRTLIQAVAKVTGATDLSNKSLRVIADHIRSCAFLIADGVMP
SNENRGYVLRRIIRRAVRHGNMLGAKETFFYKLVGPLIDVMGSAGEDLKR
QQAQVEQVLKTEEEQFARTLERGLALLDEELAKLSGDTLDGETAFRLYDT
YGFPVDLTADVCRERNIKVDEAGFEAAMEEQRRRAREASGF
3D structure
PDB3hxu Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.7: alanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A5A A R69 D76 H86 H87 F90 M92 W170 E209 N212 D235 T236 G237 G239 R242 R69 D76 H86 H87 F90 M92 W170 E209 N212 D235 T236 G237 G239 R242
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006419 alanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hxu, PDBe:3hxu, PDBj:3hxu
PDBsum3hxu
PubMed20010690
UniProtP00957|SYA_ECOLI Alanine--tRNA ligase (Gene Name=alaS)

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