Structure of PDB 3hxq Chain A

Receptor sequence
>3hxqA (length=201) Species: 9606 (Homo sapiens) [Search protein sequence]
PPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWV
RVAVVEYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYT
LFQIFSKIDRPEASRIALLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPV
GIGPHANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEA
P
3D structure
PDB3hxq A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1.
ChainA
Resolution2.694 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R524 F603 Q625 E626 P627 Q628 R629 S631 R632 N633 R636 Y637 L659 K660 R23 F102 Q124 E125 P126 Q127 R128 S130 R131 N132 R135 Y136 L158 K159 PDBbind-CN: Kd=0.6nM
External links
PDB RCSB:3hxq, PDBe:3hxq, PDBj:3hxq
PDBsum3hxq
PubMed19913482
UniProtP04275|VWF_HUMAN von Willebrand factor (Gene Name=VWF)

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