Structure of PDB 3hxo Chain A

Receptor sequence
>3hxoA (length=199) Species: 9606 (Homo sapiens) [Search protein sequence]
FYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVV
EYHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIF
SKIDRPEASRIALLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPH
ANLKQIRLIEKQAPENKAFVLSSVDELEQQRDEIVSYLCDLAPEAPPPT
3D structure
PDB3hxo A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1.
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K599 F603 Q625 E626 Q628 R629 S631 R632 N633 Y637 A657 L659 K660 K93 F97 Q119 E120 Q122 R123 S125 R126 N127 Y131 A151 L153 K154 PDBbind-CN: Kd=0.6nM
External links
PDB RCSB:3hxo, PDBe:3hxo, PDBj:3hxo
PDBsum3hxo
PubMed19913482
UniProtP04275|VWF_HUMAN von Willebrand factor (Gene Name=VWF)

[Back to BioLiP]