Structure of PDB 3hx4 Chain A

Receptor sequence
>3hx4A (length=467) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
DHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAV
KVISKDKESLLREVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGEL
FDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKS
KDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWST
GVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIR
KMLTYVPSMRISARDALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGT
QKLAQAALLYMGSKLTSQDETKELTAIFHKMDKNGDGQLDRAELIEGYKE
LMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNGYIEYSEFVTVAMDRKT
LLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSVLSEVDK
NNDGEVDFDEFQQMLLK
3D structure
PDB3hx4 Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D174 K176 E178 N179 D195 T214
Catalytic site (residue number reindexed from 1) D138 K140 E142 N143 D159 T178
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D415 D417 N419 Y421 E423 E426 D379 D381 N383 Y385 E387 E390
BS02 CA A D368 N370 D372 Q374 E379 D332 N334 D336 Q338 E343
BS03 CA A D451 D453 S455 K457 E462 D415 D417 S419 K421 E426
BS04 CA A D485 N487 D489 E491 E496 D449 N451 D453 E455 E460
BS05 ANP A V65 A78 K80 Y131 L181 V36 A49 K51 Y95 L145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calcium/calmodulin-dependent protein kinase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hx4, PDBe:3hx4, PDBj:3hx4
PDBsum3hx4
PubMed20436473
UniProtQ9BJF5

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