Structure of PDB 3hw5 Chain A

Receptor sequence

>3hw5A (length=177) Species: 93838 (Influenza A virus (A/goose/Guangdong/1/1996(H5N1)))

PLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCF
MYSRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPDLYDYKENRFIEIG
VTRREVHTYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARI
KTRLFTIRQEMASRGLWDSFRQSERGE

3D structure

• PDB: 3hw5 Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center
• Chain: A
• Resolution: 1.81 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	E80 D108	E59 D87
BS02	AMP	A	A20 I38 H41 L42 E80 G81 D108 K134	A24 I42 H45 L46 E59 G60 D87 K113

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:3hw5, PDBe:3hw5, PDBj:3hw5
• PDBsum: 3hw5
• PubMed: 19587036
• UniProt: Q9Q0U9|PA_I96A0 Polymerase acidic protein (Gene Name=PA)