Structure of PDB 3hvo Chain A

Receptor sequence
>3hvoA (length=559) Species: 11115 (Hepatitis C virus isolate HC-J8) [Search protein sequence]
SMSYTWTGALITPCGPEEEKLPINPLSNSLMRFHNKVYSTTSRSASLRAK
KVTFDRVQVLDAHYDSVLQDVKRAASKVSARLLTVEEACALTPPHSAKSR
YGFGAKEVRSLSRRAVNHIRSVWEDLLEDQHTPIDTTIMAKNEVFCIDPK
KPARLIVYPDLGVRVCEKMALYDIAQKLPKAIMGPSYGFQYSPAERVDFL
LKAWGSKKDPMGFSYDTRCFDSTVTERDIRTEESIYQACSLPQEARTVIH
SLTERLYVGGPMTNSKGQSCGYRRCRASGVFTTSMGNTMTCYIKALAACK
AAGIVDPVMLVCGDDLVVISESQGNEEDERNLRAFTEAMTRYSAPPGDLP
RPEYDLELITSCSSNVSVALDSRGRRRYFLTRDPTTPITRAAWETVRHSP
VNSWLGNIIQYAPTIWVRMVIMTHFFSILLAQDTLNQNLNFEMYGAVYSV
NPLDLPAIIERLHGLEAFSLHTYSPHELSRVAATLRKLGAPPLRAWKSRA
RAVRASLIAQGARAAICGRYLFNWAVKTKLKLTPLPEASRLDLSGWFTVG
AGGGDIYHS
3D structure
PDB3hvo Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VGI A I419 R422 M423 R498 W528 I415 R418 M419 R494 W524 BindingDB: IC50=180nM,EC50=11000nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3hvo, PDBe:3hvo, PDBj:3hvo
PDBsum3hvo
PubMed
UniProtP26661|POLG_HCVJ8 Genome polyprotein

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