Structure of PDB 3ht5 Chain A

Receptor sequence
>3ht5A (length=335) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
YHTDHMVSIDYAEGRGWHNARVIPYGPIELDPSAIVLHYAQEVFEGLKAY
RWADGSIVSFRADANAARLRSSARRLAIPELPDAVFIESLRQLIAVDKAW
VPGAGGEEALYLRPFIFATEPGLGVRPATQYRYLLIASPAGAYFKGGIAP
VSVWVSTEYVRACPGGTGAAKFGGNYAASLLAQAEAAENGCDQVVWLDAV
ERRYIEEMGGMNIFFVLGSGGSARLVTPELSGSLLPGITRDSLLQLAIDA
GFAVEERRIDIDEWQKKAAAGEITEVFACGTAAVITPVARVRHGASEFRI
ADGQPGEVTMALRDTLTGIQRGTFADTHGWMARLG
3D structure
PDB3ht5 The 1.9 A structure of the branched-chain amino-acid transaminase (IlvE) from Mycobacterium tuberculosis.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K204
Catalytic site (residue number reindexed from 1) K171
Enzyme Commision number 2.6.1.42: branched-chain-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PMP A R101 K204 Y209 E240 G243 M244 N245 L268 G270 I271 T272 T314 R68 K171 Y176 E207 G210 M211 N212 L235 G237 I238 T239 T281
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0005515 protein binding
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0052654 L-leucine-2-oxoglutarate transaminase activity
GO:0052655 L-valine-2-oxoglutarate transaminase activity
GO:0052656 L-isoleucine-2-oxoglutarate transaminase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009098 L-leucine biosynthetic process
GO:0009099 L-valine biosynthetic process
GO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
GO:0071267 L-methionine salvage

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Molecular Function
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Biological Process
External links
PDB RCSB:3ht5, PDBe:3ht5, PDBj:3ht5
PDBsum3ht5
PubMed19923721
UniProtP9WQ75|ILVE_MYCTU Branched-chain-amino-acid aminotransferase (Gene Name=ilvE)

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