Structure of PDB 3hrk Chain A

Receptor sequence
>3hrkA (length=416) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
VETEPVQGCRDFPPEAMRCRRHLFDVFHATAKTFGFEEYDAPVLESEELY
IRKAGEEITEQMFNFITKGGHRVALRPEMTPSLARLLLGKGRSLLLPAKW
YSIPQCWRYEAITRGRRREHYQWNMDIVGVKSVSAEVELVCAACWAMRSL
GLSSKDVGIKVNSRKVLQTVVEQAGVTSDKFAPVCVIVDKMEKIPREEVE
AQLAVLGLEPTVVDAITTTLSLKSIDEIAQRVGEEHEAVKELRQFFEQVE
AYGYGDWVLFDASVVRGLAYYTGIVFEGFDREGKFRALCGGGRYDNLLTT
YGSPTPIPCAGFGFGDCVIVELLQEKRLLPDIPHVVDDVVIPFDESMRPH
ALAVLRRLRDAGRSADIILDKKKVVQAFNYADRVGAVRAVLVAPEEWERG
EVQVKMLFAVPLDRLV
3D structure
PDB3hrk Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
ChainA
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.21: histidine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HAM A E126 T128 R156 E158 R164 R165 H168 Q170 D174 R314 L316 Y318 Y319 A335 L336 C337 G359 F360 G361 G363 C365 E78 T80 R108 E110 R116 R117 H120 Q122 D126 R266 L268 Y270 Y271 A287 L288 C289 G311 F312 G313 G315 C317
Gene Ontology
Molecular Function
GO:0004821 histidine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006427 histidyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3hrk, PDBe:3hrk, PDBj:3hrk
PDBsum3hrk
PubMed20132829
UniProtQ4DA54

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