Structure of PDB 3hq5 Chain A

Receptor sequence
>3hq5A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
QLIPPLINLLMSIEPDVIYAGHDNDTSSSLLTSLNQLGERQLLSVVKWSK
SLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLIL
NEQRKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGL
RSQTQFEEMRSSYIRELIKAIGLRKGVVSSSQRFYQLTKLLDNLHDLVKQ
LHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHK
3D structure
PDB3hq5 Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GKK A L718 N719 M756 M759 L763 F778 F794 M801 L887 Y890 C891 F905 L34 N35 M72 M75 L79 F94 F109 M116 L201 Y204 C205 F219 MOAD: ic50=16nM
PDBbind-CN: -logKd/Ki=7.80,IC50=16nM
BindingDB: IC50=16nM,EC50=9nM
External links
PDB RCSB:3hq5, PDBe:3hq5, PDBj:3hq5
PDBsum3hq5
PubMed19595590
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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