Structure of PDB 3hn8 Chain A

Receptor sequence

>3hn8A (length=279) Species: 10116 (Rattus norvegicus) [Search protein sequence]

GAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD
RKKKFQTKVHRKTLNPIFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHD
LIGQVVLDNLLELAEQPPDRPLWRDILEGGSEKADLGELNFSLCYLPTAG
LLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNP
TYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPEAADPHG
REHWAEMLANPRKPVEHWHQLVEEKTLSS

3D structure

PDB

3hn8 Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion.

Chain

Resolution

3.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	D328 D334 D386 F387 D388	D34 D40 D92 F93 D94
BS02	CA	A	D388 S391 R392 D394	D94 S97 R98 D100
BS03	CA	A	M459 D460 D520 D522 E528	M165 D166 D226 D228 E234
BS04	CA	A	D466 N490	D172 N196
BS05	CA	A	D460 D466 D520 Y521 D522	D166 D172 D226 Y227 D228
BS06	CA	A	K327 D328 D386 D388 D394	K33 D34 D92 D94 D100
BS07	ZN	A	D419 H543 E546	D125 H249 E252

Gene Ontology

	Cellular Component
GO:0016020	membrane

View graph for
Cellular Component

External links

PDB	RCSB:3hn8, PDBe:3hn8, PDBj:3hn8
PDBsum	3hn8
PubMed	20173762
UniProt	P40748\|SYT3_RAT Synaptotagmin-3 (Gene Name=Syt3)

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