Structure of PDB 3hmy Chain A

Receptor sequence
>3hmyA (length=442) Species: 1513 (Clostridium tetani) [Search protein sequence]
NLDCWEDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQLVPGIN
GKAIHLVNNESSEVIVHKAMDIEYNDMFNNFTVSFWLRVPKVSASHLEQY
GTNEYSIISSMKSIGSGWSVSLKGNNLIWTLKDSAGEVRQITFRDLPDKF
NAYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLK
LDRCNNNNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLR
YDTEYYLIPVASSSKDVQLKNITDYMYLTNAPSYTNGKLNIYYRRLYNGL
KFIIKRYTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPKDGNAFNNLDR
ILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNASLGLVGTHNG
QIGNDPNRDILIASNWYFNHLKDKILGCDWYFVPTDEGWTND
3D structure
PDB3hmy Gangliosides as high affinity receptors for tetanus neurotoxin.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A922 K996
Catalytic site (residue number reindexed from 1) A53 K123
Enzyme Commision number 3.4.24.68: tentoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA A D1147 N1216 I1275 D274 N343 I402
BS02 SIA A D1214 G1215 N1216 R1226 Y1229 D341 G342 N343 R353 Y356
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:3hmy, PDBe:3hmy, PDBj:3hmy
PDBsum3hmy
PubMed19602728
UniProtP04958|TETX_CLOTE Tetanus toxin (Gene Name=tetX)

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