Structure of PDB 3hmv Chain A

Receptor sequence
>3hmvA (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQ
ERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLS
TPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDES
VLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHM
SLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLE
LYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIV
HPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQNRDCQGLMEKFQFEL
T
3D structure
PDB3hmv Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H238 H274 D275 D392 H87 H123 D124 D241
BS02 HBT A M347 D392 N395 Y403 I410 M411 F414 Q443 F446 M196 D241 N244 Y252 I259 M260 F263 Q292 F295 PDBbind-CN: -logKd/Ki=7.30,IC50=50.12nM
BindingDB: IC50=50nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3hmv, PDBe:3hmv, PDBj:3hmv
PDBsum3hmv
PubMed19525117
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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