Structure of PDB 3hmp Chain A

Receptor sequence
>3hmpA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
ECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTL
DSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKK
KKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDF
GIANQMSQVGTVNYMPPEAIKDMKISPKSDVWSLGCILYYMTYGKTPFQQ
IINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELL
AHPYVQIQ
3D structure
PDB3hmp Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N556 L565 D647 K649 N652 D664 T686
Catalytic site (residue number reindexed from 1) N41 L50 D132 K134 N137 D149 T161
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CX4 A I531 C604 N606 L654 I16 C89 N91 L139 MOAD: Kd=3.24uM
PDBbind-CN: -logKd/Ki=5.49,Kd=3.24uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3hmp, PDBe:3hmp, PDBj:3hmp
PDBsum3hmp
PubMed20099905
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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