Structure of PDB 3hl4 Chain A

Receptor sequence
>3hl4A (length=176) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFH
SGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHC
RYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAG
MFAPTQRTEGISTSDIITRIVRDYDV
3D structure
PDB3hl4 Crystal Structure of a mammalian CTP: Phosphocholine cytidylyltransferase catalytic domain reveals novel active site residues within a highly conserved nucleotidyl-transferase fold
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F121 G123
Catalytic site (residue number reindexed from 1) F82 G84
Enzyme Commision number 2.7.7.15: choline-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CDC A D82 G83 I84 F85 G91 H92 A95 K122 W151 H168 D169 Y173 Y182 R196 T197 D43 G44 I45 F46 G52 H53 A56 K83 W112 H129 D130 Y134 Y143 R157 T158
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004105 choline-phosphate cytidylyltransferase activity
Biological Process
GO:0006657 CDP-choline pathway
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3hl4, PDBe:3hl4, PDBj:3hl4
PDBsum3hl4
PubMed19783652
UniProtP19836|PCY1A_RAT Choline-phosphate cytidylyltransferase A (Gene Name=Pcyt1a)

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