Structure of PDB 3hgx Chain A

Receptor sequence
>3hgxA (length=99) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
MKTPEDCTGLADIREAIDRIDLDIVQALGRRMDYVKAASRFAASEAAIPA
PERVAAMLPERARWAEENGLDAPFVEGLFAQIIHWYIAEQIKYWRQTRG
3D structure
PDB3hgx Structure-function analyses of isochorismate-pyruvate lyase from Pseudomonas aeruginosa suggest differing catalytic mechanisms for the two pericyclic reactions of this bifunctional enzyme.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.99.21: isochorismate lyase.
5.4.99.5: chorismate mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PYR A A38 Q90 A38 Q90
Gene Ontology
Molecular Function
GO:0004106 chorismate mutase activity
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0016853 isomerase activity
GO:0043904 isochorismate pyruvate lyase activity
Biological Process
GO:0009697 salicylic acid biosynthetic process
GO:0019752 carboxylic acid metabolic process
GO:0042864 pyochelin biosynthetic process
GO:0046417 chorismate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3hgx, PDBe:3hgx, PDBj:3hgx
PDBsum3hgx
PubMed19432488
UniProtQ51507|PCHB_PSEAE Isochorismate pyruvate lyase (Gene Name=pchB)

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