Structure of PDB 3hd3 Chain A

Receptor sequence
>3hd3A (length=215) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLAE
QMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPP
CTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGG
VMTSCVSEQLDHGVLLVGYNDGAAVPYWIIKNSWTTQWGEEGYIRIAKGS
NQCLVKEEASSAVVG
3D structure
PDB3hd3 Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H162 N182
Catalytic site (residue number reindexed from 1) Q19 C25 H162 N182
Enzyme Commision number 3.4.22.51: cruzipain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25B A Q19 G23 C25 S61 G65 G66 D161 H162 Q19 G23 C25 S61 G65 G66 D161 H162 PDBbind-CN: -logKd/Ki=7.00,IC50=0.1uM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3hd3, PDBe:3hd3, PDBj:3hd3
PDBsum3hd3
PubMed19773167
UniProtP25779|CYSP_TRYCR Cruzipain

[Back to BioLiP]