Structure of PDB 3hc6 Chain A

Receptor sequence
>3hc6A (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
TELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMAT
NHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPS
GHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILS
PDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFAELLGRLTELRT
FNHHHAEMLMSWRVNDHKFTPLLEEIWDVQ
3D structure
PDB3hc6 FXR agonist activity of conformationally constrained analogs of GW 4064.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A P463 L464 E467 P221 L222 E225
BS02 088 A M265 L287 T288 M290 H294 M328 F329 R331 I335 W454 M23 L45 T46 M48 H52 M86 F87 R89 I93 W212 BindingDB: EC50=210nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
GO:0035100 ecdysone binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0035076 ecdysone receptor signaling pathway
GO:0038183 bile acid signaling pathway
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:3hc6, PDBe:3hc6, PDBj:3hc6
PDBsum3hc6
PubMed19586769
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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