Structure of PDB 3hc5 Chain A

Receptor sequence
>3hc5A (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATN
HVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSG
HSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSP
DRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTF
NHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
3D structure
PDB3hc5 FXR agonist activity of conformationally constrained analogs of GW 4064.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V299 K321 P463 L464 E467 V56 K78 P220 L221 E224
BS02 82X A M265 T270 L287 T288 M290 A291 H294 M328 F329 R331 S342 Y369 H447 W454 W469 M22 T27 L44 T45 M47 A48 H51 M85 F86 R88 S99 Y126 H204 W211 W226 BindingDB: EC50=63nM
Gene Ontology
Molecular Function
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3hc5, PDBe:3hc5, PDBj:3hc5
PDBsum3hc5
PubMed19586769
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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