Structure of PDB 3hav Chain A

Receptor sequence
>3havA (length=296) Species: 1352 (Enterococcus faecium) [Search protein sequence]
MVNLDAEIYEHLNKQIKINELRYLSSGDDSDTFLCNEQYVVKVPKRDSVR
ISQKREFELYRFLENCKLSYQIPAVVYQSDRFNIMKYIKGERITYEQYHK
LSEKEKDALAYDEATFLKELHSIEIDCSVSLFSDALVNKKDKFLQDKKLL
ISILEKEQLLTDEMLEHIETIYENILNNAVLFKYTPCLVHNDFSANNMIF
RNNRLFGVIDFGDFNVGDPDNDFLCLLDCSTDDFGKEFGRKVLKYYQHKA
PEVAERKAELNDVYWSIDQIIYGYDREMLIKGVSELLQTQAEMFIF
3D structure
PDB3hav The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A S25 S30 T32 K42 M85 Y87 I88 I209 D210 S25 S30 T32 K42 M85 Y87 I88 I209 D210
BS02 SRY A D192 S194 D213 C225 D232 W265 Y272 D192 S194 D213 C225 D232 W265 Y272 PDBbind-CN: -logKd/Ki=3.77,Ki=170uM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:3hav, PDBe:3hav, PDBj:3hav
PDBsum3hav
PubMed19429619
UniProtQ9EVD7

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