Structure of PDB 3ha7 Chain A

Receptor sequence
>3ha7A (length=270) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
VSDDFFALFQDPTRTYSCAYFEPPELTLEEAQYAKVDLNLDKLDLKPGMT
LLDIGCGWGTTMRRAVERFDVNVIGLTLSKNQHARCEQVLASIDTNRSRQ
VLLQGWEDFAEPVDRIVSIEAFEHFGHENYDDFFKRCFNIMPADGRMTVQ
SSVSYHPYEARGKKLSFETARFIKFIVTEIFPGGRLPSTEMMVEHGEKAG
FTVPEPLSLRPHYIKTLRIWGDTLQSNKDKAIEVEEVYNRYMKYLRGCEH
YFTDEMLDCSLVTYLKPGAA
3D structure
PDB3ha7 SADAE, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B32 A Y42 G81 T103 L104 Q108 G131 W132 E146 A147 E149 F151 S178 F209 Y241 Y274 C278 F282 Y16 G55 T77 L78 Q82 G105 W106 E120 A121 E123 F125 S152 F181 Y213 Y244 C248 F252
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008610 lipid biosynthetic process
GO:0032259 methylation
GO:0071768 mycolic acid biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ha7, PDBe:3ha7, PDBj:3ha7
PDBsum3ha7
PubMed
UniProtQ79FX8|MMAA4_MYCTU Hydroxymycolate synthase MmaA4 (Gene Name=mmaA4)

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