Structure of PDB 3h9f Chain A

Receptor sequence
>3h9fA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
FQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQT
LDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLK
KKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLID
FGIANQMQPDTTSGTVNYMPPEAIKDMSKISPKSDVWSLGCILYYMTYGK
TPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRIS
IPELLAHPYVQIQ
3D structure
PDB3h9f Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D647 K649 N652 D664 T686
Catalytic site (residue number reindexed from 1) D133 K135 N138 D150 T165
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T675 S677 T161 S163
BS02 92M A I531 A551 I586 C604 G605 N606 I607 D608 S611 L654 D664 I17 A37 I72 C90 G91 N92 I93 D94 S97 L140 D150 PDBbind-CN: -logKd/Ki=7.92,Kd=12nM
BindingDB: IC50=342.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3h9f, PDBe:3h9f, PDBj:3h9f
PDBsum3h9f
PubMed20383151
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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