Structure of PDB 3h8c Chain A

Receptor sequence
>3h8cA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFESNKYWLVKNSWGEEWGMGGYVKMAKDR
RNHCGIASAASYPTV
3D structure
PDB3h8c A Combined Crystallographic and Molecular Dynamics Study of Cathepsin L Retrobinding Inhibitors
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H163 N187
Catalytic site (residue number reindexed from 1) Q19 C25 H163 N182
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NSZ A Q19 G20 C22 A25 G61 E63 N66 G67 G68 L69 M70 A135 A138 D162 Q19 G20 C22 A25 G61 E63 N66 G67 G68 L69 M70 A135 A138 D162 MOAD: Ki=0.019uM
PDBbind-CN: -logKd/Ki=7.72,Ki=0.019uM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3h8c, PDBe:3h8c, PDBj:3h8c
PDBsum3h8c
PubMed19761244
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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