Structure of PDB 3h8b Chain A

Receptor sequence
>3h8bA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFESNKYWLVKNSWGEEWGMGGYVKMAKDR
RNHCGIASAASYPTV
3D structure
PDB3h8b A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H163 N187
Catalytic site (residue number reindexed from 1) Q19 C25 H163 N182
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NSY A Q19 Q21 C22 G23 C25 G61 E63 G67 G68 L69 M70 A135 A138 G139 E141 L144 F145 D162 H163 W189 Q19 Q21 C22 G23 C25 G61 E63 G67 G68 L69 M70 A135 A138 G139 E141 L144 F145 D162 H163 W184 MOAD: Ki=0.511uM
PDBbind-CN: -logKd/Ki=6.29,Ki=0.511uM
BS02 NSY A R8 E9 G11 R8 E9 G11 MOAD: Ki=0.511uM
PDBbind-CN: -logKd/Ki=6.29,Ki=0.511uM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3h8b, PDBe:3h8b, PDBj:3h8b
PDBsum3h8b
PubMed19761244
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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