Structure of PDB 3h81 Chain A

Receptor sequence
>3h81A (length=256) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELDDDPDIGA
IIITGSAKAFAAGADIKEMADLTFADAFTADFFATWGKLAAVRTPTIAAV
AGYALGGGCELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIG
KAKAMDLILTGRTMDAAEAERSGLVSRVVPADDLLTEARATATTISQMSA
SAARMAKEAVNRAFESSLSEGLLYERRLFHSAFATEDQSEGMAAFIEKRA
PQFTHR
3D structure
PDB3h81 Increasing the structural coverage of tuberculosis drug targets.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A86 M91 T101 F105 G129 E132 P151 E152 V157 P159 G160 L245 F255
Catalytic site (residue number reindexed from 1) A64 M69 T79 F83 G107 E110 P129 E130 V135 P137 G138 L223 F233
Enzyme Commision number 4.2.1.17: enoyl-CoA hydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A F255 Q260 F233 Q238
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004300 enoyl-CoA hydratase activity
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Cellular Component
External links
PDB RCSB:3h81, PDBe:3h81, PDBj:3h81
PDBsum3h81
PubMed25613812
UniProtP9WNN9|ECHA8_MYCTU Probable enoyl-CoA hydratase EchA8 (Gene Name=echA8)

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