Structure of PDB 3h7w Chain A

Receptor sequence
>3h7wA (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
FKGLDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALD
SENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYPQCIMCVN
YVLSEIEK
3D structure
PDB3h7w Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B
ChainA
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 018 A H248 M252 A277 Y281 M289 S292 V302 Y307 M309 T321 C339 H13 M17 A42 Y46 M54 S57 V67 Y72 M74 T86 C98 MOAD: Kd=0.59uM
External links
PDB RCSB:3h7w, PDBe:3h7w, PDBj:3h7w
PDBsum3h7w
PubMed19950993
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

[Back to BioLiP]