Structure of PDB 3h52 Chain A

Receptor sequence
>3h52A (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
HMLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAV
KWAKAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAP
DLIINEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSV
PKDGLKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSM
HEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPGNIKKLLFHQ
3D structure
PDB3h52 Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 M593 W600 V50 K54 M68 W75
BS02 486 A N564 G567 Q570 M601 F623 Q642 M752 N39 G42 Q45 M76 F98 Q117 M227 BindingDB: IC50=1.1nM,Ki=1.2nM,EC50=872nM,Kd=15nM
External links
PDB RCSB:3h52, PDBe:3h52, PDBj:3h52
PDBsum3h52
PubMed19913032
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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