Structure of PDB 3h2x Chain A

Receptor sequence
>3h2xA (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAE
KPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYI
ATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQ
LEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPS
SIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDG
IIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK
HS
3D structure
PDB3h2x Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation .
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D195 C227 R233 T234 Q274
Catalytic site (residue number reindexed from 1) D195 C227 R233 T234 Q274
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A M130 E131 Y132 K191 M130 E131 Y132 K191
BS02 PO4 A K51 K53 N54 S82 S83 K51 K53 N54 S82 S83
BS03 PO4 A E131 Y132 K137 E131 Y132 K137
BS04 PO4 A R233 Q278 R233 Q278
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3h2x, PDBe:3h2x, PDBj:3h2x
PDBsum3h2x
PubMed19371084
UniProtQ9Y2R2|PTN22_HUMAN Tyrosine-protein phosphatase non-receptor type 22 (Gene Name=PTPN22)

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