Structure of PDB 3h0w Chain A

Receptor sequence
>3h0wA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
SMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFM
KPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFDQTL
EILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCG
YSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKP
GKFVTTLFVNQKIEGFKRLDCQSAMFNDYNFVFTSFAK
3D structure
PDB3h0w Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
ChainA
Resolution1.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S229 H243
Catalytic site (residue number reindexed from 1) S152 H166
Enzyme Commision number 4.1.1.50: adenosylmethionine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N8M A F223 C226 G227 Y228 I244 T245 E247 F146 C149 G150 Y151 I167 T168 E170 MOAD: ic50=600nM
PDBbind-CN: -logKd/Ki=6.22,IC50=600nM
BindingDB: IC50=600nM
BS02 PYR A S69 K80 H243 S1 K12 H166
Gene Ontology
Molecular Function
GO:0004014 adenosylmethionine decarboxylase activity
Biological Process
GO:0006597 spermine biosynthetic process
GO:0008295 spermidine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3h0w, PDBe:3h0w, PDBj:3h0w
PDBsum3h0w
PubMed19527050
UniProtP17707|DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (Gene Name=AMD1)

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