Structure of PDB 3h0q Chain A

Receptor sequence
>3h0qA (length=681) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PIATPYPVKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADVK
LTDDFFISNELIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGRQ
FVVVANDITFKIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIGM
AEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERTV
INGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTCR
SVGIGAYLVRLGQRAIQVEGQPIILTGAPAINKMLGREVYTSNLQLGGTQ
IMYNNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRPV
DFTPTNDETYDVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVGR
ARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQEPGQVWHPNSAFK
TAQAINDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVDY
KQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPQGMV
GIKFRREKLLDTMNRLELLPIYGQISLQFADLHDRSSRMVAKGVISKELE
WTEARRFFFWRLRRRLNEEYLIKRLSHQVGEASRLEKIARIRSWYPASVD
HEDDRQVATWIEENYKTLDDKLKGLKLESFA
3D structure
PDB3h0q Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B37 A V1923 R1954 F1956 S1957 G1958 L2025 E2026 Q2028 G2029 I2033 V442 R473 F475 S476 G477 L544 E545 Q547 G548 I552 PDBbind-CN: -logKd/Ki=6.07,IC50=842nM
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:3h0q, PDBe:3h0q, PDBj:3h0q
PDBsum3h0q
PubMed20219367
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

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