Structure of PDB 3h0a Chain A

Receptor sequence
>3h0aA (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
EDMPVERILEAELAVENDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAI
FDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREK
VYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT
PIDTFLMEML
3D structure
PDB3h0a Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V280 T449 E453 V35 T204 E208
BS02 9RA A I268 A272 Q275 L309 F313 L326 A327 F346 C432 H435 L436 I23 A27 Q30 L64 F68 L81 A82 F101 C187 H190 L191 BindingDB: EC50=33nM,Kd=36nM,Ki=379nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3h0a, PDBe:3h0a, PDBj:3h0a
PDBsum3h0a
PubMed19464171
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

[Back to BioLiP]