Structure of PDB 3h03 Chain A

Receptor sequence
>3h03A (length=257) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT
IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK
PFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAV
FDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK
PCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKW
WYDKGEC
3D structure
PDB3h03 Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UBP A Y61 P89 L90 T91 R96 T174 Y190 L192 E193 M196 Y220 Y57 P85 L86 T87 R92 T170 Y186 L188 E189 M192 Y216 MOAD: ic50=135uM
PDBbind-CN: -logKd/Ki=3.87,IC50=135uM
BS02 ZN A E42 H46 E38 H42
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3h03, PDBe:3h03, PDBj:3h03
PDBsum3h03
PubMed19284741
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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