Structure of PDB 3gz9 Chain A

Receptor sequence
>3gz9A (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
QVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKAAPFVIHDIETLWQAE
KGLVWKGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFGSLFLND
QVTLLKYGVHEAIFAMLASLVNKDGLLVANGSGFVTREFLRSLRKPFSDI
IEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTI
LRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETET
SLHPLLQEIYKD
3D structure
PDB3gz9 Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B7G A T297 K319 E471 K474 T84 K106 E258 K261
BS02 D32 A F282 R284 C285 T289 H323 L330 L339 V341 V348 I364 K367 H449 M453 L469 Y473 F69 R71 C72 T76 H110 L117 L126 V128 V135 I151 K154 H236 M240 L256 Y260 MOAD: Ki=0.004uM
PDBbind-CN: -logKd/Ki=8.40,IC50=4nM
BindingDB: EC50=54nM,Ki=4nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3gz9, PDBe:3gz9, PDBj:3gz9
PDBsum3gz9
PubMed19464171
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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