Structure of PDB 3gwu Chain A

Receptor sequence
>3gwuA (length=509) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLV
GIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVV
AIYYVYIESWTLGFAIKFLVGLVPEPPPTDPDSILRPFKEFLYSYIGVPK
GDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILA
VFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLS
LGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFF
GVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSS
IAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFW
AGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYIT
PAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAER
RRNHESAGT
3D structure
PDB3gwu Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures.
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LEU A A22 G24 G26 Y108 F253 T254 S256 F259 A18 G20 G22 Y104 F247 T248 S250 F253
BS02 SRE A L29 R30 Y108 F253 A319 D401 D404 L25 R26 Y104 F247 A313 D395 D398 MOAD: ic50=19.7uM
PDBbind-CN: -logKd/Ki=4.71,IC50=19.7uM
Gene Ontology
Biological Process
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3gwu, PDBe:3gwu, PDBj:3gwu
PDBsum3gwu
PubMed19430461
UniProtO67854

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