Structure of PDB 3gwc Chain A

Receptor sequence
>3gwcA (length=246) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
AETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPN
PKTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSY
SQLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLE
AKFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRAS
EHADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSPLA
3D structure
PDB3gwc Increasing the structural coverage of tuberculosis drug targets.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A R95 H96 R97 H98 H194 R199 H203 R94 H95 R96 H97 H193 R198 H202
BS02 UFP A R87 Q103 S105 Q106 R107 R172 R86 Q102 S104 Q105 R106 R171
BS03 FAD A C43 S71 E74 H98 N188 R190 C42 S70 E73 H97 N187 R189
BS04 FAD A S102 Q103 S101 Q102
BS05 UFP A H91 E92 R95 R199 H90 E91 R94 R198
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3gwc, PDBe:3gwc, PDBj:3gwc
PDBsum3gwc
PubMed25613812
UniProtP9WG57|THYX_MYCTU Flavin-dependent thymidylate synthase (Gene Name=thyX)

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