Structure of PDB 3gvp Chain A

Receptor sequence
>3gvpA (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
SMKQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEK
PLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALA
ESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKY
PNMFKKIKGIVEESVTGVHRLYQLAGKLCVPAMNVNDSVTKQKFDNLYCC
RESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEID
PICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCI
VCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLL
NLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVA
SLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPN
3D structure
PDB3gvp Human S-adenosyl homocysteine hydrolase-like 2 protein crystal structure
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H234 A257 S262 D310 E335 N360 K365 D369 N370 C374 H480 V531 T539 Q543
Catalytic site (residue number reindexed from 1) H62 A85 S90 D138 E163 N186 K191 D195 N196 C200 H306 V357 T365 Q369
Enzyme Commision number 3.13.2.1: adenosylhomocysteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A D369 G401 V403 T421 E422 I423 C454 T455 N457 M478 G479 N525 D195 G227 V229 T247 E248 I249 C280 T281 N283 M304 G305 N351
External links
PDB RCSB:3gvp, PDBe:3gvp, PDBj:3gvp
PDBsum3gvp
PubMed
UniProtQ96HN2|SAHH3_HUMAN Adenosylhomocysteinase 3 (Gene Name=AHCYL2)

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