Structure of PDB 3guz Chain A

Receptor sequence
>3guzA (length=165) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
MLIIETLPLLRQQIRRLRMEGKRVALVPTMGNLHDGHMKLVDEAKARADV
VAVSIFVNPMQFDRPEDLARYPRTLQEDCEKLNKRKVDLVFAPSVKEIYP
NGTETHTYVDVPGGHFRGVSTIVSKLFNLVQPDIACFGEKDFQQLALIRK
MVADMGFDIEIVGVP
3D structure
PDB3guz X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate
ChainA
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M30 H34 H37 E77 D78 K81 K151
Catalytic site (residue number reindexed from 1) M30 H34 H37 E77 D78 K81 K140
Enzyme Commision number 6.3.2.1: pantoate--beta-alanine ligase (AMP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAF A P28 T29 M30 Q61 I133 Q155 P28 T29 M30 Q61 I122 Q144 PDBbind-CN: -logKd/Ki=4.38,Kd=42uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004592 pantoate-beta-alanine ligase activity
Biological Process
GO:0009058 biosynthetic process
GO:0015940 pantothenate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3guz, PDBe:3guz, PDBj:3guz
PDBsum3guz
PubMed20059543
UniProtP31663|PANC_ECOLI Pantothenate synthetase (Gene Name=panC)

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