Structure of PDB 3gta Chain A

Receptor sequence
>3gtaA (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]
GPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQDKVRCFFC
YGGLQSWKRGDDPWTEHAKWFPGCQFLLRSKGQEYINNIH
3D structure
PDB3gta Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F81
Catalytic site (residue number reindexed from 1) F4
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C124 C127 H144 C151 C47 C50 H67 C74
BS02 851 A K121 R123 G130 L131 Q132 W134 D138 E143 W147 K44 R46 G53 L54 Q55 W57 D61 E66 W70 PDBbind-CN: -logKd/Ki=4.28,Ki=53uM
BindingDB: Ki=53000nM
External links
PDB RCSB:3gta, PDBe:3gta, PDBj:3gta
PDBsum3gta
PubMed20189383
UniProtQ96CA5|BIRC7_HUMAN Baculoviral IAP repeat-containing protein 7 (Gene Name=BIRC7)

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