Structure of PDB 3grv Chain A

Receptor sequence
>3grvA (length=262) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
QCFLIDKNFVNKAVESANLTKDDVVLEIGLGKGILTEELAKNAKKVYVIE
IDKSLEPYANKLKELYNNIEIIWGDALKVDLNKLDFNKVVANLPYQISSP
ITFKLIKRGFDLAVLMYQYEFAKRMVAAAGTKDYGRLSVAVQSRADVEIV
AKVPPSAFYPKPKVYSAIVKIKPNKGKYHIENENFFDDFLRAIFQHRNKS
VRKALIDSSKELNYNKDEMKKILEDFLNTNSEIKNLINEKVFKLSVKDIV
NLSNEFYRFLQN
3D structure
PDB3grv Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G38 E59 N101 Y104 F167
Catalytic site (residue number reindexed from 1) G29 E50 N92 Y95 F158
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN A C11 G40 E59 I60 D84 A85 P103 C2 G31 E50 I51 D75 A76 P94
Gene Ontology
Molecular Function
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0016433 rRNA (adenine) methyltransferase activity
GO:0016740 transferase activity
Biological Process
GO:0000154 rRNA modification
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3grv, PDBe:3grv, PDBj:3grv
PDBsum3grv
PubMed20163168
UniProtQ58435|RSMA_METJA Probable ribosomal RNA small subunit methyltransferase A (Gene Name=rsmA)

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