Structure of PDB 3gqc Chain A

Receptor sequence

>3gqcA (length=435) Species: 9606 (Homo sapiens)

SDCNFISNFYSHSRLHHISMWKCELTEFVNTLQRFPGREKLKKQSCIMHV
DMDCFFVSVGIRNRPDLKGKPVAVTSNRGTGRAPLRPGANPQLEWQYYQN
KILKGIDSVLSRAEIASCSYEARQLGIKNGMFFGHAKQLCPNLQAVPYDF
HAYKEVAQTLYETLASYTHNIEAVSCDEALVDITEILAETKLTPDEFANA
VRMEIKDQTKCAASVGIGSNILLARMATRKAKPDGQYHLKPEEVDDFIRG
QLVTNLPGVGHSMESKLASLGIKTCGDLQYMTMAKLQKEFGPKTGQMLYR
FCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRRL
EATGMKGKRLTLKIMVRKPGAPVETAKFGGHGICDNIARTVTLDQATDNA
KIIGKAMLNMFHTMKLNISDMRGVGIHVNQLVPTN

3D structure

• PDB: 3gqc Structure of the human Rev1-DNA-dNTP ternary complex.
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R618 G651 G653 S655 M656 R752 T783	R225 G258 G260 S262 M263 R359 T390
BS02	dna	A	F352 Y353 H355 S356 R357 L358 H359 S362 S448 A455 P456 S504 R505 A506 K686 T687 R709 K710 S713 A714 E715 N717 Y718 R742 K770 F771 G773 H774 G775	F9 Y10 H12 S13 R14 L15 H16 S19 S76 A83 P84 S111 R112 A113 K293 T294 R316 K317 S320 A321 E322 N324 Y325 R349 K377 F378 G380 H381 G382
BS03	dna	A	P725 K726	P332 K333
BS04	DCP	A	R357 D425 C426 F427 F428 A509 S510 Y513 R516 N522 D570 K625	R14 D53 C54 F55 F56 A116 S117 Y120 R123 N129 D177 K232
BS05	MG	A	D423 M424 D570	D51 M52 D177
BS06	MG	A	D570 E571	D177 E178
BS07	MG	A	T447 S448 E507 Y541	T75 S76 E114 Y148
BS08	MG	A	T647 L649 V652	T254 L256 V259

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:3gqc, PDBe:3gqc, PDBj:3gqc
• PDBsum: 3gqc
• PubMed: 19464298
• UniProt: Q9UBZ9|REV1_HUMAN DNA repair protein REV1 (Gene Name=REV1)